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Gene expression profiles in normal and Otx2-/- early gastrulating mouse embryos.


ABSTRACT: The mouse Otx2 gene is a homeobox transcription factor required as early as gastrulation for the proper development of the head. We compared gene expression profiles in wild-type and Otx2(-/-) 6.5 days postcoitum embryos by using a serial analysis of gene expression assay adapted to microdissected structures. Among a broader list, the study of six genes found to be differentially expressed allows defining a role for Otx2 in the orchestration of cell movements leading to the adequate organization of the embryo before gastrulation.

SUBMITTER: Zakin L 

PROVIDER: S-EPMC18928 | biostudies-literature | 2000 Dec

REPOSITORIES: biostudies-literature

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Gene expression profiles in normal and Otx2-/- early gastrulating mouse embryos.

Zakin L L   Reversade B B   Virlon B B   Rusniok C C   Glaser P P   Elalouf J M JM   Brulet P P  

Proceedings of the National Academy of Sciences of the United States of America 20001201 26


The mouse Otx2 gene is a homeobox transcription factor required as early as gastrulation for the proper development of the head. We compared gene expression profiles in wild-type and Otx2(-/-) 6.5 days postcoitum embryos by using a serial analysis of gene expression assay adapted to microdissected structures. Among a broader list, the study of six genes found to be differentially expressed allows defining a role for Otx2 in the orchestration of cell movements leading to the adequate organization  ...[more]

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