Ontology highlight
ABSTRACT:
SUBMITTER: Zakin L
PROVIDER: S-EPMC18928 | biostudies-literature | 2000 Dec
REPOSITORIES: biostudies-literature
Zakin L L Reversade B B Virlon B B Rusniok C C Glaser P P Elalouf J M JM Brulet P P
Proceedings of the National Academy of Sciences of the United States of America 20001201 26
The mouse Otx2 gene is a homeobox transcription factor required as early as gastrulation for the proper development of the head. We compared gene expression profiles in wild-type and Otx2(-/-) 6.5 days postcoitum embryos by using a serial analysis of gene expression assay adapted to microdissected structures. Among a broader list, the study of six genes found to be differentially expressed allows defining a role for Otx2 in the orchestration of cell movements leading to the adequate organization ...[more]