Ontology highlight
ABSTRACT:
SUBMITTER: Pilo Boyl P
PROVIDER: S-EPMC1894775 | biostudies-literature | 2007 Jun
REPOSITORIES: biostudies-literature
The EMBO journal 20070531 12
Profilins are actin binding proteins essential for regulating cytoskeletal dynamics, however, their function in the mammalian nervous system is unknown. Here, we provide evidence that in mouse brain profilin1 and profilin2 have distinct roles in regulating synaptic actin polymerization with profilin2 preferring a WAVE-complex-mediated pathway. Mice lacking profilin2 show a block in synaptic actin polymerization in response to depolarization, which is accompanied by increased synaptic excitabilit ...[more]