Bone marrow dysfunction in mice lacking the cytokine receptor gp130 in endothelial cells.
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ABSTRACT:
SUBMITTER: Yao L
PROVIDER: S-EPMC1895244 | biostudies-literature | 2005 Dec
REPOSITORIES: biostudies-literature
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Bone marrow dysfunction in mice lacking the cytokine receptor gp130 in endothelial cells.
Yao Longbiao L Yokota Takafumi T Xia Lijun L Kincade Paul W PW McEver Rodger P RP
Blood 20050823 13
In vitro studies suggest that bone marrow endothelial cells contribute to multilineage hematopoiesis, but this function has not been studied in vivo. We used a Cre/loxP-mediated recombination to produce mice that lacked the cytokine receptor subunit gp130 in hematopoietic and endothelial cells. Although normal at birth, the mice developed bone marrow dysfunction that was accompanied by splenomegaly caused by extramedullary hematopoiesis. The hypocellular marrow contained myeloerythroid progenito ...[more]
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