Ontology highlight
ABSTRACT:
SUBMITTER: Serrano LM
PROVIDER: S-EPMC1895371 | biostudies-literature | 2006 Apr
REPOSITORIES: biostudies-literature
Serrano Lisa Marie LM Pfeiffer Timothy T Olivares Simon S Numbenjapon Tontanai T Bennitt Jennifer J Kim Daniel D Smith David D McNamara George G Al-Kadhimi Zaid Z Rosenthal Joseph J Forman Stephen J SJ Jensen Michael C MC Cooper Laurence J N LJ
Blood 20051213 7
Disease relapse is a barrier to achieving therapeutic success after unrelated umbilical cord-blood transplantation (UCBT) for B-lineage acute lymphoblastic leukemia (B-ALL). While adoptive transfer of donor-derived tumor-specific T cells is a conceptually attractive approach to eliminating residual disease after allogeneic hematopoietic stem cell transplantation, adoptive immunotherapy after UCBT is constrained by the difficulty of generating antigen-specific T cells from functionally naive umbi ...[more]