Ontology highlight
ABSTRACT:
SUBMITTER: Piqueras B
PROVIDER: S-EPMC1895384 | biostudies-literature | 2006 Apr
REPOSITORIES: biostudies-literature
Piqueras Bernard B Connolly John J Freitas Heidi H Palucka Anna Karolina AK Banchereau Jacques J
Blood 20051129 7
Host response to viral infection involves distinct effectors of innate and adaptive immunity, whose mobilization needs to be coordinated to ensure protection. Here we show that influenza virus triggers, in human blood dendritic-cell (DC) subsets (ie, plasmacytoid and myeloid DCs), a coordinated chemokine (CK) secretion program with 3 successive waves. The first one, occurring at early time points (2 to 4 hours), includes CKs potentially attracting effector cells such as neutrophils, cytotoxic T ...[more]