Ontology highlight
ABSTRACT:
SUBMITTER: Stirewalt DL
PROVIDER: S-EPMC1895777 | biostudies-literature | 2006 May
REPOSITORIES: biostudies-literature
Stirewalt Derek L DL Kopecky Kenneth J KJ Meshinchi Soheil S Engel Julia H JH Pogosova-Agadjanyan Era L EL Linsley Jeremy J Slovak Marilyn L ML Willman Cheryl L CL Radich Jerald P JP
Blood 20051220 9
FLT3 internal tandem duplications (FLT3/ITDs) in the juxtamembrane domain are found in approximately 25% of acute myeloid leukemia (AML) patients, ranging in size from 3 to hundreds of nucleotides. We examined whether the sizes of FLT3/ITDs were associated with clinical outcomes in 151 AML patients enrolled in Southwest Oncology Group studies: S9333 and S9500. FLT3/ITDs were identified in 32% of patients (median ITD size = 39 nucleotides; range, 15-153 nucleotides). The CR rates were 35%, 67%, a ...[more]