Profiling signaling polarity in chemotactic cells.
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ABSTRACT:
SUBMITTER: Wang Y
PROVIDER: S-EPMC1895949 | biostudies-literature | 2007 May
REPOSITORIES: biostudies-literature
Publications
Profiling signaling polarity in chemotactic cells.
Wang Yingchun Y Ding Shi-Jian SJ Wang Wei W Jacobs Jon M JM Qian Wei-Jun WJ Moore Ronald J RJ Yang Feng F Camp David G DG Smith Richard D RD Klemke Richard L RL
Proceedings of the National Academy of Sciences of the United States of America 20070509 20
Cell movement requires morphological polarization characterized by formation of a leading pseudopodium (PD) at the front and a trailing rear at the back. However, little is known about how protein networks are spatially integrated to regulate this process at the system level. Here, we apply global proteome profiling in combination with newly developed quantitative phosphoproteomics approaches for comparative analysis of the cell body (CB) and PD proteome of chemotactic cells. The spatial relatio ...[more]
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