Ontology highlight
ABSTRACT:
SUBMITTER: Simmons SJ
PROVIDER: S-EPMC1896056 | biostudies-literature | 2007 Apr
REPOSITORIES: biostudies-literature
Simmons Susan J SJ Peddada Shyamal D SD
Bioinformation 20070410 10
This article extends the order restricted inference approach for time-course or dose-response gene expression microarray data, introduced by Peddada and colleagues (2003) for the case when gene expression is heteroscedastic over time or dose. The new methodology uses an iterative algorithm to estimate mean expression at various times/doses when mean expression is subject to pre-defined patterns or profiles, known as order-restrictions. Simulation studies reveal that the resulting bootstrap-based ...[more]