Ontology highlight
ABSTRACT:
SUBMITTER: Jung Y
PROVIDER: S-EPMC1896130 | biostudies-literature | 2007 Jul
REPOSITORIES: biostudies-literature
Jung Younghun Y Wang Jingcheng J Song Junhui J Shiozawa Yusuke Y Wang Jianhua J Havens Aaron A Wang Zhuo Z Sun Yan-Xi YX Emerson Stephen G SG Krebsbach Paul H PH Taichman Russell S RS
Blood 20070314 1
Differentiation of hematopoietic stem cells (HSCs) after birth is largely restricted to the bone marrow cavity, where HSCs are associated closely with osteoblasts (OBs). How OBs localize HSCs to the endosteal niche remains unclear. To explore adhesive interactions between HSCs and OBs, a cell blot analysis was used that revealed 2 major bands that corresponded to monomers and multimers of annexin II (Anxa2). Immunohistochemistry revealed that OBs and marrow endothelial cells express Anxa2 at hig ...[more]