Ontology highlight
ABSTRACT:
SUBMITTER: Govin J
PROVIDER: S-EPMC1896149 | biostudies-literature | 2006 Dec
REPOSITORIES: biostudies-literature
Govin Jérôme J Caron Cécile C Escoffier Emmanuelle E Ferro Myriam M Kuhn Lauriane L Rousseaux Sophie S Eddy Edward M EM Garin Jérôme J Khochbin Saadi S
The Journal of biological chemistry 20061011 49
HSPA2 (formerly HSP70.2) is a testis-specific member of the HSP70 family known to play a critical role in the completion of meiosis during male germ cell differentiation. Although abundantly present in post-meiotic cells, its function during spermiogenesis remained obscure. Here, using a global proteomic approach to identify genome-organizing proteins in condensing spermatids, we discovered an unexpected role for HSPA2, which acquires new functions and becomes tightly associated with major sperm ...[more]