Ontology highlight
ABSTRACT:
SUBMITTER: Eriksson U
PROVIDER: S-EPMC1899532 | biostudies-literature | 2007 Feb
REPOSITORIES: biostudies-literature
Eriksson Ulrika U Hilfinger John M JM Kim Jae-Seung JS Mitchell Stefanie S Kijek Paul P Borysko Katherine Z KZ Breitenbach Julie M JM Drach John C JC Kashemirov Boris A BA McKenna Charles E CE
Bioorganic & medicinal chemistry letters 20061110 3
Cidofovir (HPMPC) is a broad-spectrum anti-viral agent whose potential, particularly in biodefense scenarios, is limited by its low oral bioavailability. Two prodrugs (3 and 4) created by conjugating ethylene glycol-linked amino acids (L-Val, L-Phe) with the cyclic form of cidofovir (cHPMPC) via a P-O ester bond were synthesized and their pH-dependent stability (3 and 4), potential for in vivo reconversion to drug (3), and oral bioavailability (3) were evaluated. The prodrugs were stable in buff ...[more]