Ontology highlight
ABSTRACT:
SUBMITTER: Funnell AP
PROVIDER: S-EPMC1899893 | biostudies-literature | 2007 Apr
REPOSITORIES: biostudies-literature
Funnell Alister P W AP Maloney Christopher A CA Thompson Lucinda J LJ Keys Janelle J Tallack Michael M Perkins Andrew C AC Crossley Merlin M
Molecular and cellular biology 20070205 7
The Sp/Krüppel-like factor (Sp/Klf) family is comprised of around 25 zinc finger transcription factors that recognize CACCC boxes and GC-rich elements. We have investigated basic Krüppel-like factor (Bklf/Klf3) and show that in erythroid tissues its expression is highly dependent on another family member, erythroid Krüppel-like factor (Eklf/Klf1). We observe that Bklf mRNA is significantly reduced in erythroid tissues from Eklf-null murine embryos. We find that Bklf is driven primarily by two pr ...[more]