Ontology highlight
ABSTRACT:
SUBMITTER: Klattig J
PROVIDER: S-EPMC1900060 | biostudies-literature | 2007 Jun
REPOSITORIES: biostudies-literature
Klattig Jürgen J Sierig Ralph R Kruspe Dagmar D Besenbeck Birgit B Englert Christoph C
Molecular and cellular biology 20070409 12
The Wilms' tumor protein Wt1 plays an essential role in mammalian urogenital development. WT1 mutations in humans lead to a variety of disorders, including Wilms' tumor, a pediatric kidney cancer, as well as Frasier and Denys-Drash syndromes. Phenotypic anomalies in Denys-Drash syndrome include pseudohermaphroditism and sex reversal in extreme cases. We have used cDNA microarray analyses on Wt1 knockout mice to identify Wt1-dependent genes involved in sexual development. The gene most dramatical ...[more]