Ontology highlight
ABSTRACT:
SUBMITTER: Azarova AM
PROVIDER: S-EPMC1904155 | biostudies-literature | 2007 Jun
REPOSITORIES: biostudies-literature
Azarova Anna M AM Lyu Yi Lisa YL Lin Chao-Po CP Tsai Yuan-Chin YC Lau Johnson Yiu-Nam JY Wang James C JC Liu Leroy F LF
Proceedings of the National Academy of Sciences of the United States of America 20070619 26
Drugs that target DNA topoisomerase II (Top2), including etoposide (VP-16), doxorubicin, and mitoxantrone, are among the most effective anticancer drugs in clinical use. However, Top2-based chemotherapy has been associated with higher incidences of secondary malignancies, notably the development of acute myeloid leukemia in VP-16-treated patients. This association is suggestive of a link between carcinogenesis and Top2-mediated DNA damage. We show here that VP-16-induced carcinogenesis involves ...[more]