Ontology highlight
ABSTRACT:
SUBMITTER: Vardhanabhuti S
PROVIDER: S-EPMC1904283 | biostudies-literature | 2007
REPOSITORIES: biostudies-literature
Vardhanabhuti Saran S Wang Junwen J Hannenhalli Sridhar S
Nucleic acids research 20070422 10
Computational discovery of cis-regulatory elements remains challenging. To cope with the high false positives, evolutionary conservation is routinely used. However, conservation is only one of the attributes of cis-regulatory elements and is neither necessary nor sufficient. Here, we assess two additional attributes--positional and inter-motif distance specificity--that are critical for interactions between transcription factors. We first show that for a greater than expected fraction of known m ...[more]