Ontology highlight
ABSTRACT:
SUBMITTER: Lau AL
PROVIDER: S-EPMC1904418 | biostudies-literature | 2007 Jul
REPOSITORIES: biostudies-literature
Lau Anthony L AL Yam Alice Y AY Michelitsch Melissa M D MM Wang Xuemei X Gao Carol C Goodson Robert J RJ Shimizu Robert R Timoteo Gulliver G Hall John J Medina-Selby Angelica A Coit Doris D McCoin Colin C Phelps Bruce B Wu Ping P Hu Celine C Chien David D Peretz David D
Proceedings of the National Academy of Sciences of the United States of America 20070629 28
On our initial discovery that prion protein (PrP)-derived peptides were capable of capturing the pathogenic prion protein (PrP(Sc)), we have been interested in how these peptides interact with PrP(Sc). After screening peptides from the entire human PrP sequence, we found two peptides (PrP(19-30) and PrP(100-111)) capable of binding full-length PrP(Sc) in plasma, a medium containing a complex mixture of other proteins including a vast excess of the normal prion protein (PrP(C)). The limit of dete ...[more]