Cross-modal regulation of synaptic AMPA receptors in primary sensory cortices by visual experience.
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ABSTRACT:
SUBMITTER: Goel A
PROVIDER: S-EPMC1905492 | biostudies-literature | 2006 Aug
REPOSITORIES: biostudies-literature
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Cross-modal regulation of synaptic AMPA receptors in primary sensory cortices by visual experience.
Goel Anubhuthi A Jiang Bin B Xu Linda W LW Song Lihua L Kirkwood Alfredo A Lee Hey-Kyoung HK
Nature neuroscience 20060702 8
Lack of a sensory input not only alters the cortical circuitry subserving the deprived sense, but also produces compensatory changes in the functionality of other sensory modalities. Here we report that visual deprivation produces opposite changes in synaptic function in primary visual and somatosensory cortices in rats, which are rapidly reversed by visual experience. This type of bidirectional cross-modal plasticity is associated with changes in synaptic AMPA receptor subunit composition. ...[more]
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