Ontology highlight
ABSTRACT:
SUBMITTER: Alberts R
PROVIDER: S-EPMC1906859 | biostudies-literature | 2007
REPOSITORIES: biostudies-literature
Alberts Rudi R Terpstra Peter P Li Yang Y Breitling Rainer R Nap Jan-Peter JP Jansen Ritsert C RC
PloS one 20070718 7
Many investigations have reported the successful mapping of quantitative trait loci (QTLs) for gene expression phenotypes (eQTLs). Local eQTLs, where expression phenotypes map to the genes themselves, are of especially great interest, because they are direct candidates for previously mapped physiological QTLs. Here we show that many mapped local eQTLs in genetical genomics experiments do not reflect actual expression differences caused by sequence polymorphisms in cis-acting factors changing mRN ...[more]