Ontology highlight
ABSTRACT:
SUBMITTER: Ravindran R
PROVIDER: S-EPMC1907313 | biostudies-literature | 2007 Jul
REPOSITORIES: biostudies-literature
Ravindran Rajesh R Rusch Lori L Itano Andrea A Jenkins Marc K MK McSorley Stephen J SJ
Proceedings of the National Academy of Sciences of the United States of America 20070705 29
The contribution of CCR6 and phagocyte recruitment to the initiation of T cell responses to a local pathogen is unclear. CD4 T cell activation to an injected soluble antigen occurred rapidly and was completely CCR6-independent. In marked contrast, the tempo of pathogen-specific CD4 T cell activation depended on whether the antigen was secreted or cell-associated. Furthermore, lymph node pathogen-specific CD4 T cell activation required CCR6 and cell migration from the site of infection. Surprisin ...[more]