Ontology highlight
ABSTRACT:
SUBMITTER: Sutter JA
PROVIDER: S-EPMC1907361 | biostudies-literature | 2006 Sep
REPOSITORIES: biostudies-literature
Pediatric endocrinology reviews : PER 20060901 1
Adrenocortical tumors are rare in children and are associated with a poor prognosis when malignant. The fund of knowledge regarding etiology, presentation and clinical outcomes remains limited. Evaluation of genetic disorders associated with the development of adrenocortical disorders has allowed researchers to identify a number of mutations that may be involved in tumorigenesis, including alterations in the GNAS1, PRKAR1A, TP53 and IGF2 genes. Clinical presentation in children is associated mos ...[more]