Ontology highlight
ABSTRACT:
SUBMITTER: Lehrmann E
PROVIDER: S-EPMC1907635 | biostudies-literature | 2003
REPOSITORIES: biostudies-literature
Lehrmann E E Oyler J J Vawter M P MP Hyde T M TM Kolachana B B Kleinman J E JE Huestis M A MA Becker K G KG Freed W J WJ
The pharmacogenomics journal 20030101 1
CNS-focused cDNA microarrays were used to examine gene expression profiles in dorsolateral prefrontal cortex (dlPFC, Area 46) from seven individual sets of age- and post-mortem interval-matched male cocaine abusers and controls. The presence of cocaine and related metabolites was confirmed by gas chromatography-mass spectrometry. Sixty-five transcripts were differentially expressed, indicating alterations in energy metabolism, mitochondria and oligodendrocyte function, cytoskeleton and related s ...[more]