Ontology highlight
ABSTRACT:
SUBMITTER: Deghorain M
PROVIDER: S-EPMC1913409 | biostudies-literature | 2007 Jun
REPOSITORIES: biostudies-literature
Deghorain Marie M Goffin Philippe P Fontaine Laetitia L Mainardi Jean-Luc JL Daniel Richard R Errington Jeff J Hallet Bernard B Hols Pascal P
Journal of bacteriology 20070330 11
Lactobacillus plantarum produces peptidoglycan precursors ending in D-lactate instead of D-alanine, making the bacterium intrinsically resistant to vancomycin. The ligase Ddl of L. plantarum plays a central role in this specificity by synthesizing D-alanyl-D-lactate depsipeptides that are added to the precursor peptide chain by the enzyme MurF. Here we show that L. plantarum also encodes a D-Ala-D-Ala dipeptidase, Aad, which eliminates D-alanyl-D-alanine dipeptides that are produced by the Ddl l ...[more]