MHC class I A region diversity and polymorphism in macaque species.
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ABSTRACT:
SUBMITTER: Otting N
PROVIDER: S-EPMC1914291 | biostudies-literature | 2007 May
REPOSITORIES: biostudies-literature
Publications
MHC class I A region diversity and polymorphism in macaque species.
Otting Nel N de Vos-Rouweler Annemiek J M AJ Heijmans Corrine M C CM de Groot Natasja G NG Doxiadis Gaby G M GG Bontrop Ronald E RE
Immunogenetics 20070303 5
The HLA-A locus represents a single copy gene that displays abundant allelic polymorphism in the human population, whereas, in contrast, a nonhuman primate species such as the rhesus macaque (Macaca mulatta) possesses multiple HLA-A-like (Mamu-A) genes, which parade varying degrees of polymorphism. The number and combination of transcribed Mamu-A genes present per chromosome display diversity in a population of Indian animals. At present, it is not clearly understood whether these different A re ...[more]
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