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Linkage study of 14 candidate genes and loci in four large Dutch families with vesico-ureteral reflux.

ABSTRACT: Vesico-ureteral reflux (VUR) is a major contributing factor to end-stage renal disease in paediatric patients. Primary VUR is a familial disorder, but little is known about its genetic causes. To investigate the involvement of 12 functional candidate genes and two reported loci in VUR, we performed a linkage study in four large, Dutch, multi-generational families with multiple affected individuals. We were unable to detect linkage to any of the genes and loci and could exclude the GDNF, RET, SLIT2, SPRY1, PAX2, AGTR2, UPK1A and UPK3A genes and the 1p13 and 20p13 loci from linkage to VUR. Our results provide further evidence that there appears to be genetic heterogeneity in VUR.

SUBMITTER: van Eerde AM

PROVIDER: S-EPMC1915619 | biostudies-literature | 2007 Aug

REPOSITORIES: biostudies-literature

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Linkage study of 14 candidate genes and loci in four large Dutch families with vesico-ureteral reflux.

van Eerde Albertien M AM Koeleman Bobby P C BP van de Kamp Jiddeke M JM de Jong Tom P V M TP Wijmenga Cisca C Giltay Jacques C JC

Pediatric nephrology (Berlin, Germany) 20070512 8

Vesico-ureteral reflux (VUR) is a major contributing factor to end-stage renal disease in paediatric patients. Primary VUR is a familial disorder, but little is known about its genetic causes. To investigate the involvement of 12 functional candidate genes and two reported loci in VUR, we performed a linkage study in four large, Dutch, multi-generational families with multiple affected individuals. We were unable to detect linkage to any of the genes and loci and could exclude the GDNF, RET, SLI ...[more]

PMID: 17497182

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