Ontology highlight
ABSTRACT:
SUBMITTER: Vandenbroucke RE
PROVIDER: S-EPMC1919477 | biostudies-literature | 2007
REPOSITORIES: biostudies-literature
Vandenbroucke Roosmarijn E RE Lucas Bart B Demeester Joseph J De Smedt Stefaan C SC Sanders Niek N NN
Nucleic acids research 20070621 12
One of the major obstacles in non-viral gene transfer is the nuclear membrane. Attempts to improve the transport of DNA to the nucleus through the use of nuclear localization signals or importin-beta have achieved limited success. It has been proposed that the nuclear pore complexes (NPCs) through which nucleocytoplasmic transport occurs are filled with a hydrophobic phase through which hydrophobic importins can dissolve. Therefore, considering the hydrophobic nature of the NPC channel, we evalu ...[more]