Ontology highlight
ABSTRACT:
SUBMITTER: Li X
PROVIDER: S-EPMC19206 | biostudies-literature | 1998 Feb
REPOSITORIES: biostudies-literature
Li X X Chen S S Wang Q Q Zack D J DJ Snyder S H SH Borjigin J J
Proceedings of the National Academy of Sciences of the United States of America 19980201 4
The circadian hormone melatonin is synthesized predominantly in the pineal gland by the actions of two pineal-specific enzymes: serotonin N-acetyltransferase (NAT) and hydroxyindole-O-methyltransferase (HIOMT). Pineal night-specific ATPase (PINA), another pineal- and night-specific protein we recently identified, is produced as a truncated form of the Wilson disease gene (Atp7b) product. To identify the regulatory elements required for pineal-specific gene expression, we isolated sequences upstr ...[more]