Ontology highlight
ABSTRACT:
SUBMITTER: Petrovas C
PROVIDER: S-EPMC1924769 | biostudies-literature | 2007 Aug
REPOSITORIES: biostudies-literature
Petrovas Constantinos C Price David A DA Mattapallil Joseph J Ambrozak David R DR Geldmacher Christof C Cecchinato Valentina V Vaccari Monica M Tryniszewska Elzbieta E Gostick Emma E Roederer Mario M Douek Daniel C DC Morgan Sara H SH Davis Simon J SJ Franchini Genoveffa G Koup Richard A RA
Blood 20070417 3
Programmed death-1 (PD-1) is a critical mediator of virus-specific CD8+ T-cell exhaustion. Here, we examined the expression of PD-1 on simian immunodeficiency virus (SIV)-specific CD8+ T cells and its possible involvement in regulation of cytokine production, proliferation, and survival of these cells. The majority of SIV-specific CD8+ T cells expressed a PD-1(high) phenotype, independent of their differentiation status, in all tissues tested. PD-1 expression gradually declined on CD8+ T cells s ...[more]