Global transcriptional responses of fission and budding yeast to changes in copper and iron levels: a comparative study.

ABSTRACT:

Background

Recent studies in comparative genomics demonstrate that interspecies comparison represents a powerful tool for identifying both conserved and specialized biologic processes across large evolutionary distances. All cells must adjust to environmental fluctuations in metal levels, because levels that are too low or too high can be detrimental. Here we explore the conservation of metal homoeostasis in two distantly related yeasts.

Results

We examined genome-wide gene expression responses to changing copper and iron levels in budding and fission yeast using DNA microarrays. The comparison reveals conservation of only a small core set of genes, defining the copper and iron regulons, with a larger number of additional genes being specific for each species. Novel regulato

SUBMITTER: Rustici G 

PROVIDER: S-EPMC1929147 | biostudies-literature | 2007

REPOSITORIES: biostudies-literature