Dataset Information

Effects of abdominal hot compresses on indocyanine green elimination--a randomized cross over study in healthy subjects.

ABSTRACT:

Background

Hot compresses on the right upper abdomen are used as support for patients with liver diseases in Germany. The study was designed to determine, whether they affect hepatic blood flow.

Methods

Single dose kinetics of indocyanine green (ICG) were studied in 13 healthy subjects with or without hot compresses on the right upper abdomen over 40 minutes. The time interval between the investigations was 8 days, the sequence was randomly assigned.

Results

Within non-linear kinetic analyses the area under the curves (AUC) were 23% (95% confidence interval [CI]: 5-37%) lower with hot compresses. In the initial phase, however, no differences were detected (p = 0.295). The differences occurred only in the late phase after 30-40 minutes, when the genuine ICG is eliminated from the plasma and only the degradation product remains.

Conclusion

Hot compresses have no effect on ICG elimination in healthy subjects but seem to affect the elimination of ICG metabolites.

Trial registration

ClinicalTrials.gov NCT00484913.

SUBMITTER: Huber R

PROVIDER: S-EPMC1931598 | biostudies-literature | 2007 Jul

REPOSITORIES: biostudies-literature

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Publications

Effects of abdominal hot compresses on indocyanine green elimination--a randomized cross over study in healthy subjects.

Huber Roman R Weisser Sven S Luedtke Rainer R

BMC gastroenterology 20070710

<h4>Background</h4>Hot compresses on the right upper abdomen are used as support for patients with liver diseases in Germany. The study was designed to determine, whether they affect hepatic blood flow.<h4>Methods</h4>Single dose kinetics of indocyanine green (ICG) were studied in 13 healthy subjects with or without hot compresses on the right upper abdomen over 40 minutes. The time interval between the investigations was 8 days, the sequence was randomly assigned.<h4>Results</h4>Within non-line ...[more]

PMID: 17623067

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Project description:BACKGROUND: To investigate indocyanine green angiography (ICGA) findings in patients with long-standing Vogt-Koyanagi-Harada (VKH) disease and their correlation with disease activity on clinical examination as well as with systemic corticosteroid therapy. METHODS: Twenty-eight patients (51 eyes) with long-standing (?6 months from disease onset) VKH disease whose treatment was tapered based only in clinical features were prospectively included at a single center in Brazil. All patients underwent standardized clinical evaluation, which included fundus photography, fluorescein angiography and ICGA. Clinical disease activity was determined based in the Standardization in Uveitis Nomenclature Working Group. Fisher exact test and logistic regression models were used for statistical analysis. RESULTS: Disease-related choroidal inflammation on ICGA was observed in 72.5% (31 of 51 eyes). Angiographic findings suggestive of (choroidal and/or retinal) disease activity were not observed on FA. Clinically active disease based on clinical evaluation was observed in 41.2% (21 of 51 eyes). In these 21 eyes, disease-related choroidal inflammation on ICGA was observed in 76.2% (16 of 21 eyes); in the remaining eyes (without clinical active disease) disease-related choroidal inflammation on ICGA was observed in 70.0% (21 of 30 eyes). In respect to systemic corticosteroid therapy, 10 patients (18 of 51 eyes) were under treatment with prednisone. In these 10 (18 of 51 eyes) patients, disease-related choroidal inflammation on ICGA was observed in 83.3% (15 of 18 eyes); in the remaining patients (33 of 51 eyes) disease-related choroidal inflammation on ICGA was observed in 66.7% (22 of 33 eyes). CONCLUSION: ICGA findings suggestive of disease-related choroidal inflammation were observed in a considerable proportion of patients with long-standing VKH disease, independent of the inflammatory status of the disease on clinical examination or current use of systemic corticosteroid. Therefore, the current study reinforces the crucial role of ICGA to assist the management and treatment of patients with long-standing VKH disease.

Dataset Information

Effects of abdominal hot compresses on indocyanine green elimination--a randomized cross over study in healthy subjects.

Background

Methods

Results

Conclusion

Trial registration

Publications

Effects of abdominal hot compresses on indocyanine green elimination--a randomized cross over study in healthy subjects.

Similar Datasets

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