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GeneTrail--advanced gene set enrichment analysis.


ABSTRACT: We present a comprehensive and efficient gene set analysis tool, called 'GeneTrail' that offers a rich functionality and is easy to use. Our web-based application facilitates the statistical evaluation of high-throughput genomic or proteomic data sets with respect to enrichment of functional categories. GeneTrail covers a wide variety of biological categories and pathways, among others KEGG, TRANSPATH, TRANSFAC, and GO. Our web server provides two common statistical approaches, 'Over-Representation Analysis' (ORA) comparing a reference set of genes to a test set, and 'Gene Set Enrichment Analysis' (GSEA) scoring sorted lists of genes. Besides other newly developed features, GeneTrail's statistics module includes a novel dynamic-programming algorithm that improves the P-value computation of GSEA methods considerably. GeneTrail is freely accessible at http://genetrail.bioinf.uni-sb.de.

SUBMITTER: Backes C 

PROVIDER: S-EPMC1933132 | biostudies-literature | 2007 Jul

REPOSITORIES: biostudies-literature

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GeneTrail--advanced gene set enrichment analysis.

Backes Christina C   Keller Andreas A   Kuentzer Jan J   Kneissl Benny B   Comtesse Nicole N   Elnakady Yasser A YA   Müller Rolf R   Meese Eckart E   Lenhof Hans-Peter HP  

Nucleic acids research 20070525 Web Server issue


We present a comprehensive and efficient gene set analysis tool, called 'GeneTrail' that offers a rich functionality and is easy to use. Our web-based application facilitates the statistical evaluation of high-throughput genomic or proteomic data sets with respect to enrichment of functional categories. GeneTrail covers a wide variety of biological categories and pathways, among others KEGG, TRANSPATH, TRANSFAC, and GO. Our web server provides two common statistical approaches, 'Over-Representat  ...[more]

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