Ontology highlight
ABSTRACT:
SUBMITTER: Pauwels F
PROVIDER: S-EPMC1933266 | biostudies-literature | 2007 Jul
REPOSITORIES: biostudies-literature
Pauwels Frederik F Mostmans Wendy W Quirynen Ludo M M LM van der Helm Liesbet L Boutton Carlo W CW Rueff Anne-Stéphanie AS Cleiren Erna E Raboisson Pierre P Surleraux Dominique D Nyanguile Origène O Simmen Kenneth A KA
Journal of virology 20070425 13
The search for hepatitis C virus polymerase inhibitors has resulted in the identification of several nonnucleoside binding pockets. The shape and nature of these binding sites differ across and even within diverse hepatitis C virus genotypes. These differences confront antiviral drug discovery with the challenge of finding compounds that are capable of inhibition in variable binding pockets. To address this, we have established a hepatitis C virus mutant and genotypic recombinant polymerase pane ...[more]