Herpes simplex virus type 1 cytoplasmic envelopment requires functional Vps4.
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ABSTRACT:
SUBMITTER: Crump CM
PROVIDER: S-EPMC1933334 | biostudies-literature | 2007 Jul
REPOSITORIES: biostudies-literature
Publications
Herpes simplex virus type 1 cytoplasmic envelopment requires functional Vps4.
Crump Colin M CM Yates Catherine C Minson Tony T
Journal of virology 20070516 14
The assembly and egress of herpesviruses are complex processes that require the budding of viral nucleocapsids into the lumen of cytoplasmic compartments to form mature infectious virus. This envelopment stage shares many characteristics with the formation of luminal vesicles in multivesicular endosomes. Through expression of dominant-negative Vps4, an enzyme that is essential for the formation of luminal vesicles in multivesicular endosomes, we now show that Vps4 function is required for the cy ...[more]
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