Ontology highlight
ABSTRACT:
SUBMITTER: Berman AJ
PROVIDER: S-EPMC1933411 | biostudies-literature | 2007 Jul
REPOSITORIES: biostudies-literature
Berman Andrea J AJ Kamtekar Satwik S Goodman Jessica L JL Lázaro José M JM de Vega Miguel M Blanco Luis L Salas Margarita M Steitz Thomas A TA
The EMBO journal 20070705 14
Replicative DNA polymerases (DNAPs) move along template DNA in a processive manner. The structural basis of the mechanism of translocation has been better studied in the A-family of polymerases than in the B-family of replicative polymerases. To address this issue, we have determined the X-ray crystal structures of phi29 DNAP, a member of the protein-primed subgroup of the B-family of polymerases, complexed with primer-template DNA in the presence or absence of the incoming nucleoside triphospha ...[more]