Ontology highlight
ABSTRACT:
SUBMITTER: Amante FH
PROVIDER: S-EPMC1934517 | biostudies-literature | 2007 Aug
REPOSITORIES: biostudies-literature
Amante Fiona H FH Stanley Amanda C AC Randall Louise M LM Randall Louise M LM Zhou Yonghong Y Haque Ashraful A McSweeney Karli K Waters Andrew P AP Janse Chris J CJ Good Michael F MF Hill Geoff R GR Engwerda Christian R CR
The American journal of pathology 20070628 2
Cerebral malaria (CM) is a serious complication of Plasmodium falciparum infection that is responsible for a significant number of deaths in children and nonimmune adults. A failure to control blood parasitemia and subsequent sequestration of parasites to brain microvasculature are thought to be key events in many CM cases. Here, we show for the first time, to our knowledge, that CD4(+)CD25(+)Foxp3(+) natural regulatory T (Treg) cells contribute to pathogenesis by modulating immune responses in ...[more]