Ontology highlight
ABSTRACT:
SUBMITTER: Piper DR
PROVIDER: S-EPMC193596 | biostudies-literature | 2003 Sep
REPOSITORIES: biostudies-literature
Piper David R DR Varghese Anthony A Sanguinetti Michael C MC Tristani-Firouzi Martin M
Proceedings of the National Academy of Sciences of the United States of America 20030819 18
HERG (human ether-a-go-go-related gene) encodes a delayed rectifier K+ channel vital to normal repolarization of cardiac action potentials. Attenuation of repolarizing K+ current caused by mutations in HERG or channel block by common medications prolongs ventricular action potentials and increases the risk of arrhythmia and sudden death. The critical role of HERG in maintenance of normal cardiac electrical activity derives from its unusual gating properties. Opposite to other voltage-gated K+ ch ...[more]