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Stress generation and filament turnover during actin ring constriction.

ABSTRACT: We present a physical analysis of the dynamics and mechanics of contractile actin rings. In particular, we analyze the dynamics of ring contraction during cytokinesis in the Caenorhabditis elegans embryo. We present a general analysis of force balances and material exchange and estimate the relevant parameter values. We show that on a microscopic level contractile stresses can result from both the action of motor proteins, which cross-link filaments, and from the polymerization and depolymerization of filaments in the presence of end-tracking cross-linkers.

SUBMITTER: Zumdieck A

PROVIDER: S-EPMC1936222 | biostudies-literature | 2007 Aug

REPOSITORIES: biostudies-literature

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Stress generation and filament turnover during actin ring constriction.

Zumdieck Alexander A Kruse Karsten K Bringmann Henrik H Hyman Anthony A AA Jülicher Frank F

PloS one 20070808 8

We present a physical analysis of the dynamics and mechanics of contractile actin rings. In particular, we analyze the dynamics of ring contraction during cytokinesis in the Caenorhabditis elegans embryo. We present a general analysis of force balances and material exchange and estimate the relevant parameter values. We show that on a microscopic level contractile stresses can result from both the action of motor proteins, which cross-link filaments, and from the polymerization and depolymerizat ...[more]

PMID: 17684545

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