Ontology highlight
ABSTRACT:
SUBMITTER: Huyton T
PROVIDER: S-EPMC1937536 | biostudies-literature | 2007 Jul
REPOSITORIES: biostudies-literature
Huyton Trevor T Zhang Jian-Guo JG Luo Cindy S CS Lou Mei-Zhen MZ Hilton Douglas J DJ Nicola Nicos A NA Garrett Thomas P J TP
Proceedings of the National Academy of Sciences of the United States of America 20070724 31
Leukemia inhibitory factor (LIF) receptor is a cell surface receptor that mediates the actions of LIF and other IL-6 type cytokines through the formation of high-affinity signaling complexes with gp130. Here we present the crystal structure of a complex of mouse LIF receptor with human LIF at 4.0 A resolution. The structure is, to date, the largest cytokine receptor fragment determined by x-ray crystallography. The binding of LIF to its receptor via the central Ig-like domain is unlike other cyt ...[more]