Ontology highlight
ABSTRACT:
SUBMITTER: Mittrucker HW
PROVIDER: S-EPMC1941486 | biostudies-literature | 2007 Jul
REPOSITORIES: biostudies-literature
Mittrücker Hans-Willi HW Steinhoff Ulrich U Köhler Anne A Krause Marion M Lazar Doris D Mex Peggy P Miekley Delia D Kaufmann Stefan H E SH
Proceedings of the National Academy of Sciences of the United States of America 20070718 30
Mycobacterium bovis bacille Calmette-Guérin (BCG) is the most widely used live bacterial vaccine. However, limited information is available correlating route and dose of vaccination and induction of specific T cell responses with protection against tuberculosis. We compared efficacy of oral and systemic vaccination and correlated vaccine-induced T cell responses with protection in experimental tuberculosis of mice. After oral and systemic vaccination, we observed profound differences in persiste ...[more]