Ontology highlight
ABSTRACT:
SUBMITTER: McNamara CR
PROVIDER: S-EPMC1941642 | biostudies-literature | 2007 Aug
REPOSITORIES: biostudies-literature
McNamara Colleen R CR Mandel-Brehm Josh J Bautista Diana M DM Siemens Jan J Deranian Kari L KL Zhao Michael M Hayward Neil J NJ Chong Jayhong A JA Julius David D Moran Magdalene M MM Fanger Christopher M CM
Proceedings of the National Academy of Sciences of the United States of America 20070808 33
The formalin model is widely used for evaluating the effects of analgesic compounds in laboratory animals. Injection of formalin into the hind paw induces a biphasic pain response; the first phase is thought to result from direct activation of primary afferent sensory neurons, whereas the second phase has been proposed to reflect the combined effects of afferent input and central sensitization in the dorsal horn. Here we show that formalin excites sensory neurons by directly activating TRPA1, a ...[more]