Hypoalgesia in mice with a targeted deletion of the tachykinin 1 gene.
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ABSTRACT:
SUBMITTER: Zimmer A
PROVIDER: S-EPMC19441 | biostudies-literature | 1998 Mar
REPOSITORIES: biostudies-literature
Publications
Hypoalgesia in mice with a targeted deletion of the tachykinin 1 gene.
Zimmer A A Zimmer A M AM Baffi J J Usdin T T Reynolds K K König M M Palkovits M M Mezey E E
Proceedings of the National Academy of Sciences of the United States of America 19980301 5
The tachykinin neuropeptides, substance P and substance K, are produced in nociceptive primary sensory neurons and in many brain regions involved in pain signaling. However, the precise role and importance of these neuropeptides in pain responses has been debated. We now show that mice that cannot produce these peptides display no significant pain responses following formalin injection and have an increased pain threshold in the hotplate test. On the other hand, the mutant mice react normally in ...[more]
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