Ontology highlight
ABSTRACT:
SUBMITTER: Van Herreweghe E
PROVIDER: S-EPMC1949012 | biostudies-literature | 2007 Aug
REPOSITORIES: biostudies-literature
Van Herreweghe Elodie E Egloff Sylvain S Goiffon Isabelle I Jády Beáta E BE Froment Carine C Monsarrat Bernard B Kiss Tamás T
The EMBO journal 20070705 15
The 7SK small nuclear RNA (snRNA) regulates RNA polymerase II transcription elongation by controlling the protein kinase activity of the positive transcription elongation factor b (P-TEFb). In cooperation with HEXIM1, the 7SK snRNA sequesters P-TEFb into the kinase-inactive 7SK/HEXIM1/P-TEFb small nuclear ribonucleoprotein (snRNP), and thereby, controls the nuclear level of active P-TEFb. Here, we report that a fraction of HeLa 7SK snRNA that is not involved in 7SK/HEXIM1/P-TEFb formation, speci ...[more]