Ontology highlight
ABSTRACT:
SUBMITTER: Camus G
PROVIDER: S-EPMC1949356 | biostudies-literature | 2007 Aug
REPOSITORIES: biostudies-literature
Camus Grégory G Segura-Morales Carolina C Molle Dorothee D Lopez-Vergès Sandra S Begon-Pescia Christina C Cazevieille Chantal C Schu Peter P Bertrand Edouard E Berlioz-Torrent Clarisse C Basyuk Eugenia E
Molecular biology of the cell 20070530 8
Retroviral assembly is driven by Gag, and nascent viral particles escape cells by recruiting the machinery that forms intralumenal vesicles of multivesicular bodies. In this study, we show that the clathrin adaptor complex AP-1 is involved in retroviral release. The absence of AP-1mu obtained by genetic knock-out or by RNA interference reduces budding of murine leukemia virus (MLV) and HIV-1, leading to a delay of viral propagation in cell culture. In contrast, overexpression of AP-1mu enhances ...[more]