Evaluation of gene expression profiling in a mouse model of L-gulonolactone oxidase gene deficiency.
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SUBMITTER: Yan J
PROVIDER: S-EPMC1950136 | biostudies-literature | 2007
REPOSITORIES: biostudies-literature
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Evaluation of gene expression profiling in a mouse model of L-gulonolactone oxidase gene deficiency.
Yan Jian J Jiao Yan Y Li Xinmin X Jiao Feng F Beamer Wesley G WG Rosen Cliff J CJ Gu Weikuan W
Genetics and molecular biology 20070101 2
Humans and guinea pigs are species which are unable to synthesize ascorbic acid (vitamin C) because, unlike rodents, they lack the enzyme L-gulonolactone oxidase (Gulo). Although the phenotype of lacking vitamin C in humans, named scurvy, has long been well known, information on the impact of lacking Gulo on the gene expression profiles of different tissues is still missing. This knowledge could improve our understanding of molecular pathways in which Gulo may be involved. Recently, we discovere ...[more]
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