Ontology highlight
ABSTRACT:
SUBMITTER: Kim J
PROVIDER: S-EPMC1950443 | biostudies-literature | 2007 Jun
REPOSITORIES: biostudies-literature
Kim Jinhyun J Jung Sung-Cherl SC Clemens Ann M AM Petralia Ronald S RS Hoffman Dax A DA
Neuron 20070601 6
Voltage-gated A-type K+ channel Kv4.2 subunits are highly expressed in the dendrites of hippocampal CA1 neurons. However, little is known about the subcellular distribution and trafficking of Kv4.2-containing channels. Here we provide evidence for activity-dependent trafficking of Kv4.2 in hippocampal spines and dendrites. Live imaging and electrophysiological recordings showed that Kv4.2 internalization is induced rapidly upon glutamate receptor stimulation. Kv4.2 internalization was clathrin m ...[more]