Ontology highlight
ABSTRACT:
SUBMITTER: See J
PROVIDER: S-EPMC1950488 | biostudies-literature | 2007 May
REPOSITORIES: biostudies-literature
See Jill J Mamontov Polina P Ahn Kyung K Wine-Lee Lara L Crenshaw E Bryan EB Grinspan Judith B JB
Molecular and cellular neurosciences 20070223 1
Bone morphogenetic proteins have been implicated in the development of oligodendrocytes and astrocytes, however, a role for endogenous BMP signaling in glial development has not been demonstrated in a genetic model. Using mice in which signaling via type I BMP receptors Bmpr1a and Bmpr1b have been inactivated in the neural tube, we demonstrate that BMP signaling contributes to the maturation of glial cells in vivo. At P0, mutant mice exhibited a 25-40% decrease in GFAP+ or S100beta+ astrocytes i ...[more]