Ontology highlight
ABSTRACT:
SUBMITTER: Paradis S
PROVIDER: S-EPMC1950560 | biostudies-literature | 2007 Jan
REPOSITORIES: biostudies-literature
Neuron 20070101 2
We report the results of a genetic screen to identify molecules important for synapse formation and/or maintenance. siRNAs were used to decrease the expression of candidate genes in neurons, and synapse development was assessed. We surveyed 22 cadherin family members and demonstrated distinct roles for cadherin-11 and cadherin-13 in synapse development. Our screen also revealed roles for the class 4 Semaphorins Sema4B and Sema4D in the development of glutamatergic and/or GABAergic synapses. We f ...[more]