Environment determines fidelity for an RNA virus replicase.
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ABSTRACT:
SUBMITTER: Pita JS
PROVIDER: S-EPMC1951419 | biostudies-literature | 2007 Sep
REPOSITORIES: biostudies-literature
Publications
Environment determines fidelity for an RNA virus replicase.
Pita Justin S JS de Miranda Joachim R JR Schneider William L WL Roossinck Marilyn J MJ
Journal of virology 20070606 17
The rate of insertion and deletion mutations of the replicase of Cucumber mosaic virus (CMV) was determined in planta by using a parasitic satellite RNA (satRNA) as a reporter. We found that the CMV replicase had different fidelity in different environments, with important implications in viral disease evolution. Insertions were very rare events, irrespective of the region of the satRNA genome assayed and independent of the hosts tested. On the other hand, deletion events were more frequent but ...[more]
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