Ontology highlight
ABSTRACT:
SUBMITTER: Nelson SA
PROVIDER: S-EPMC1951770 | biostudies-literature | 2007 Sep
REPOSITORIES: biostudies-literature
Nelson Scott A SA Cooper John A JA
Molecular biology of the cell 20070705 9
In budding yeast, the spindle position checkpoint (SPC) delays mitotic exit until the mitotic spindle moves into the neck between the mother and bud. This checkpoint works by inhibiting the mitotic exit network (MEN), a signaling cascade initiated and controlled by Tem1, a small GTPase. Tem1 is regulated by a putative guanine exchange factor, Lte1, but the function and regulation of Lte1 remains poorly understood. Here, we identify novel components of the checkpoint that operate upstream of Lte1 ...[more]