Ontology highlight
ABSTRACT:
SUBMITTER: Huang FT
PROVIDER: S-EPMC1952116 | biostudies-literature | 2007 Aug
REPOSITORIES: biostudies-literature
Huang Feng-Ting FT Yu Kefei K Balter Barbara B BB Selsing Erik E Oruc Zeliha Z Khamlichi Ahmed Amine AA Hsieh Chih-Lin CL Lieber Michael R MR
Molecular and cellular biology 20070611 16
The mechanism by which the cytidine deaminase activation-induced deaminase (AID) acts at immunoglobulin heavy-chain class switch regions during mammalian class switch recombination (CSR) remains unclear. R-loops have been proposed as a basis for this targeting. Here, we show that the difference between various forms of the Smu locus that can or cannot undergo CSR correlates well with the locations and detectability of R-loops. The Smu R-loops can initiate hundreds of base pairs upstream of the c ...[more]