Ontology highlight
ABSTRACT:
SUBMITTER: Ho AT
PROVIDER: S-EPMC1952122 | biostudies-literature | 2007 Aug
REPOSITORIES: biostudies-literature
Ho Andrew T AT Li Qin H QH Okada Hitoshi H Mak Tak W TW Zacksenhaus Eldad E
Molecular and cellular biology 20070611 16
The current model for the intrinsic apoptotic pathway holds that mitochondrial activation of caspases in response to cytotoxic drugs requires both Apaf-1-induced dimerization of procaspase 9 and Smac/Diablo-mediated sequestration of inhibitors of apoptosis proteins (IAPs). Here, we showed that either pathway can independently promote caspase 9 activation in response to apoptotic stimuli. In drug-treated Apaf-1(-/-) primary myoblasts, but not fibroblasts, Smac/Diablo accumulates in the cytosol an ...[more]